UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Both GABA(A) and GABA(B) receptors mediate vagal inhibition in nucleus tractus solitarii neurones in anaesthetized rats

Wang, Y; Jordan, D; Ramage, AG; (2010) Both GABA(A) and GABA(B) receptors mediate vagal inhibition in nucleus tractus solitarii neurones in anaesthetized rats. AUTON NEUROSCI-BASIC , 152 (1-2) 75 - 83. 10.1016/j.autneu.2009.10.005.

Full text not available from this repository.

Abstract

GABA receptors in the nucleus tractus solitarius (NTS) are known to play an important role in the mediation/modulation of various cardiovascular/respiratory functions. Vagal afferent activation of these neurones usually evokes an initial excitation followed by a long lasting inhibition. The present study examines the role of GABA(B) as well as GABA(A) receptors in the mediation of this inhibition in anaesthetized rats, using CGP 35348 and bicuculline, respective antagonists at these receptors, applied topically or by ionophoresis. Bicuculline delayed the onset and reduced the duration of this inhibition. The duration of this inhibition was further and significantly decreased when CGP 35348 was administered along with bicuculline but the delay in onset was unaffected. CGP 35348 application alone, had no effect on the vagal afferent-evoked inhibition. From intracellular recordings the early and late components of this inhibition were found to have reversal potentials close to E-Cl and E-K, respectively. Therefore it is concluded that this inhibition is mediated by both GABA(A) and GABA(B) receptors. although GABA(B) mediated inhibition can only be unmasked when GABA(A) receptors are blocked. (C) 2009 Elsevier B.V. All rights reserved.

Type:Article
Title:Both GABA(A) and GABA(B) receptors mediate vagal inhibition in nucleus tractus solitarii neurones in anaesthetized rats
DOI:10.1016/j.autneu.2009.10.005
Keywords:Nucleus tractus solitarius (NTS), Vagal inhibition, Vagal afferent, GABA receptors, Rat, GAMMA-AMINOBUTYRIC-ACID, CAT, ACTIVATION, AUTORECEPTORS, BACLOFEN, INPUTS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Neuroscience, Physiology and Pharmacology

Archive Staff Only: edit this record