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Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: An fMRI study

Whalley, MG; Rugg, MD; Smith, APR; Dolan, RJ; Brewin, CR; (2009) Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: An fMRI study. BRAIN COGNITION , 69 (1) 98 - 107. 10.1016/j.bandc.2008.05.008. Gold open access

Abstract

In the present study, we used fMRI to assess patients suffering from post-traumatic stress disorder (PTSD) or depression, and trauma-exposed controls, during an episodic memory retrieval task that included nontrauma-related emotional information. In the study phase of the task neutral pictures were presented in emotional or neutral contexts. Participants were scanned during the test phase, when they were presented with old and new neutral images in a yes/no recognition memory task. fMRI results for the contrast between old and new items revealed activation in a predominantly left-sided network of cortical regions including the left middle temporal, bilateral posterior cingulate, and left prefrontal cortices. Activity common to all three groups when correctly judging pictures encoded in emotional contexts was much more limited. Relative to the control and depressed groups the PTSD group exhibited greater sensitivity to correctly recognised stimuli in the left amygdala/ventral striatum and right occipital cortex, and more specific sensitivity to items encoded in emotional contexts in the right precuneus, left superior frontal gyrus, and bilateral insula. These results are consistent with a substantially intact neural system supporting episodic retrieval in patients suffering from PTSD. Moreover, there was little indication that PTSD is associated with a marked change in the way negatively valenced information, not of personal significance, is processed. (C) 2008 Elsevier Inc. All rights reserved.

Type:Article
Title:Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: An fMRI study
Open access status:An open access publication
DOI:10.1016/j.bandc.2008.05.008
Publisher version:http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2666800/?tool=pubmed
Keywords:PTSD, Memory, Trauma, Imaging, CHILDHOOD SEXUAL-ABUSE, SCRIPT-DRIVEN IMAGERY, PREFRONTAL CORTEX, EPISODIC MEMORY, RECOGNITION MEMORY, AMYGDALA RESPONSE, BRAIN ACTIVATION, VENTRAL STRIATUM, FUNCTIONAL MRI, BLOOD-FLOW
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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