Bestmann, S; Ruff, CC; Blankenburg, F; Weiskopf, N; Driver, J; Rothwell, JC; (2008) Mapping causal interregional influences with concurrent TMS-fMRI. EXP BRAIN RES , 191 (4) 383 - 402. 10.1007/s00221-008-1601-8.
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Transcranial magnetic stimulation (TMS) produces a direct causal effect on brain activity that can now be studied by new approaches that simultaneously combine TMS with neuroimaging methods, such as functional magnetic resonance imaging (fMRI). In this review we highlight recent concurrent TMS-fMRI studies that illustrate how this novel combined technique may provide unique insights into causal interactions among brain regions in humans. We show how fMRI can detect the spatial topography of local and remote TMS effects and how these may vary with psychological factors such as task-state. Concurrent TMS-fMRI may furthermore reveal how the brain adapts to so-called virtual lesions induced by TMS, and the distributed activity changes that may underlie the behavioural consequences often observed during cortical stimulation with TMS. We argue that combining TMS with neuroimaging techniques allows a further step in understanding the physiological underpinnings of TMS, as well as the neural correlated of TMS-evoked consequences on perception and behaviour. This can provide powerful new insights about causal interactions among brain regions in both health and disease that may ultimately lead to developing more efficient protocols for basic research and therapeutic TMS applications.
|Title:||Mapping causal interregional influences with concurrent TMS-fMRI|
|Keywords:||Effective connectivity, Dorsal premotor cortex, Top-down control, Virtual lesion, State-dependence, Neuroimaging, TRANSCRANIAL MAGNETIC STIMULATION, HUMAN MOTOR CORTEX, POSITRON-EMISSION-TOMOGRAPHY, DORSAL PREMOTOR CORTEX, CEREBRAL-BLOOD-FLOW, HEMOGLOBIN-CONCENTRATION CHANGES, NEAR-INFRARED SPECTROSCOPY, HUMAN PREFRONTAL CORTEX, PRIMARY VISUAL-CORTEX, ECHOPLANAR BOLD FMRI|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Motor Neuroscience and Movement Disorders
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
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