Venugopal, V and Hausenloy, DJ and Ludman, A and Di Salvo, C and Kolvekar, S and Yap, J and Lawrence, D and Bognolo, J and Yellon, DM (2009) Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial. HEART , 95 (19) 1567 - 1571. 10.1136/hrt.2008.155770.
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Background: Remote ischaemic preconditioning (RIPC) induced by brief ischaemia and reperfusion of the arm reduces myocardial injury in coronary artery bypass (CABG) surgery patients receiving predominantly cross-clamp fibrillation for myocardial protection. However, coldblood cardioplegia is the more commonly used method world wide.Objective: To assess whether RIPC is cardioprotective in CABG patients receiving cold-blood cardioplegia.Design: Single-centre, single-blinded, randomised controlled trial.Setting: Tertiary referral hospital in London.Patients: Adults patients (18-80 years) undergoing elective CABG surgery with or without concomitant aortic valve surgery with cold-blood cardioplegia. Patients with diabetes, renal failure (serum creatinine > 130 mmol/l), hepatic or pulmonary disease, unstable angina or myocardial infarction within the past 4 weeks were excluded.Interventions: Patients were randomised to receive either RIPC (n = 23) or control (n = 22) after anaesthesia. RIPC comprised three 5 min cycles of right forearm ischaemia, induced by inflating a blood pressure cuff on the upper arm to 200 mm Hg, with an intervening 5 min reperfusion. The control group had a deflated cuff placed on the upper arm for 30 min.Main outcome measures: Serum troponin T was measured preoperatively and at 6, 12, 24, 48 and 72 h after surgery and the area under the curve (AUC at 72 h) calculated.Results: RIPC reduced absolute serum troponin T release by 42.4% (mean (SD) AUC at 72 h: 31.53 (24.04) mu g/l. 72 h in controls vs 18.16 (6.67) mg/l. 72 h in RIPC; 95% Cl 2.4 to 24.3; p = 0.019).Conclusions: Remote ischaemic preconditioning induced by brief ischaemia and reperfusion of the arm reduces myocardial injury in CABG surgery patients undergoing cold-blood cardioplegia, making this non-invasive cardioprotective technique widely applicable clinically.
|Title:||Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial|
|Keywords:||BYPASS GRAFT-SURGERY, TROPONIN-T, SHORT-TERM, PROTECTION, MORTALITY, HEART, REVASCULARIZATION, ELEVATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Cardiovascular Medicine|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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