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Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities.

Hamilton, PA; Hope, PL; Cady, EB; Delpy, DT; Wyatt, JS; Reynolds, EO; (1986) Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities. Lancet , 1 (8492) pp. 1242-1246. 10.1016/s0140-6736(86)91388-7.

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Abstract

Intracellular energy metabolism was studied by phosphorus magnetic resonance spectroscopy in the brains of 27 preterm and term infants with increased echodensities consistent with hypoxic-ischaemic injury and 18 comparable normal infants. In the normal infants the phosphocreatine (PCr)/inorganic orthophosphate (Pi) ratio increased significantly from 0.77 +/- 0.24 (95% confidence limits) at a gestational plus postnatal age of 28 weeks to 1.09 +/- 0.24 at 42 weeks. 9 of the 15 infants with increased echodensities whose PCr/Pi ratios fell below the normal range died; in all 6 survivors cerebral atrophy developed (cysts in brain tissue or microcephaly). In contrast, all 12 infants with increased echodensities whose PCr/Pi ratios remained within the normal range survived, although cerebral atrophy developed in 3 with ratios towards the lower limit of normal.

Type: Article
Title: Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities.
Location: England
DOI: 10.1016/s0140-6736(86)91388-7
Keywords: Age Factors, Brain, Brain Ischemia, Cerebral Hemorrhage, Energy Metabolism, Female, Follow-Up Studies, Humans, Infant, Newborn, Infant, Premature, Diseases, Magnetic Resonance Spectroscopy, Male, Phosphates, Phosphocreatine, Ultrasonography
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/178378
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