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fMRI evidence for a cortical hierarchy of pitch pattern processing

Stewart, L; Overath, T; Warren, JD; Foxton, JM; Griffiths, TD; (2008) fMRI evidence for a cortical hierarchy of pitch pattern processing. PLoS ONE , 3 (1) , Article e1470. 10.1371/journal.pone.0001470. Green and gold open access

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Abstract

Pitch patterns, such as melodies, consist of two levels of structure: a global level, comprising the pattern of ups and downs, or contour; and a local level, comprising the precise intervals that make up this contour. An influential neuropsychological model suggests that these two levels of processing are hierarchically linked, with processing of the global structure occurring within the right hemisphere in advance of local processing within the left. However, the predictions of this model and its anatomical basis have not been tested in neurologically normal individuals. The present study used fMRI and required participants to listen to consecutive pitch sequences while performing a same/different one-back task. Sequences, when different, either preserved (local) or violated (global) the contour of the sequence preceding them. When the activations for the local and global conditions were contrasted directly, additional activation was seen for local processing in right planum temporale and posterior superior temporal sulcus (pSTS). The presence of additional activation for local over global processing supports the hierarchical view that the global structure of a pitch sequence acts as a “framework” on which the local detail is subsequently hung. However, the lateralisation of activation seen in the present study, with global processing occurring in left pSTS and local processing occurring bilaterally, differed from that predicted by the neuroanatomical model. A re-examination of the individual lesion data on which the neuroanatomical model is based revealed that the lesion data equally well support the laterality scheme suggested by our data. While the present study supports the hierarchical view of local and global processing, there is an evident need for further research, both in patients and neurologically normal individuals, before an understanding of the functional lateralisation of local and global processing can be considered established.

Type:Article
Title:fMRI evidence for a cortical hierarchy of pitch pattern processing
Open access status:An open access publication. A version is also available from UCL Discovery.
DOI:10.1371/journal.pone.0001470
Publisher version:http://dx.doi.org/10.1371/journal.pone.0001470
Language:English
Additional information:© 2008 Stewart et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work is supported by the Wellcome Trust (UK). LS is supported by an academic fellowship awarded by Research Councils UK (RCUK). TO is supported by the German Academic Exchange Service. JDW is supported by a Wellcome Trust Intermediate Clinical Fellowship.
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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