UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The genetics of Parkinson's syndromes: a critical review

Hardy, J; Lewis, P; Revesz, T; Lees, A; Paisan-Ruiz, C; (2009) The genetics of Parkinson's syndromes: a critical review. CURR OPIN GENET DEV , 19 (3) 254 - 265. 10.1016/j.gde.2009.03.008.

Full text not available from this repository.

Abstract

Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.

Type: Article
Title: The genetics of Parkinson's syndromes: a critical review
DOI: 10.1016/j.gde.2009.03.008
Keywords: ALPHA-SYNUCLEIN GENE, HALLERVORDEN-SPATZ-SYNDROME, BRAIN IRON ACCUMULATION, RECESSIVE JUVENILE PARKINSONISM, AUTOSOMAL-DOMINANT PARKINSONISM, PROGRESSIVE SUPRANUCLEAR PALSY, EARLY-ONSET PARKINSONISM, ALZHEIMERS-DISEASE, LEWY BODIES, GAUCHER-DISEASE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/177851
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item