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Prostate-specific antigen testing in hypogonadism: Implications for the safety of testosterone-replacement therapy

Gould, DC; Feneley, MR; Kirby, RS; (2006) Prostate-specific antigen testing in hypogonadism: Implications for the safety of testosterone-replacement therapy. BJU INT , 98 (1) 1 - 4.

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Abstract

Hypogonadal men have lower prostate volumes and serum prostate-specific antigen (PSA) levels than age-matched controls. When present, prostate cancer in hypogonadal men is more aggressive than in eugonadal men, and given the lack of specificity of PSA for diagnosing prostate cancer, a more accurate test would be desirable in hypogonadal men. Once testosterone-replacement therapy is started in hypogonadal men, PSA levels should be measured regularly; however, there is often an initial rise 3-6 months after starting treatment. A rise of > 0.5 ng/mL within this time requires further investigation.

Type: Article
Title: Prostate-specific antigen testing in hypogonadism: Implications for the safety of testosterone-replacement therapy
Keywords: testosterone, hypogonadism, PSA, prostate cancer, uPM3, BONE-MINERAL DENSITY, SEXUAL FUNCTION, TRANSDERMAL TESTOSTERONE, BODY-COMPOSITION, OLDER MEN, CANCER, RECOMMENDATIONS, MALES, UNDECANOATE, INJECTIONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: http://discovery.ucl.ac.uk/id/eprint/177827
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