Eva, LJ and Rolfe, KJ and MacLean, AB and Reid, WMN and Fong, ACWT and Crow, J and Perrett, CW (2007) Is localized, provoked vulvodynia an inflammatory condition? JOURNAL OF REPRODUCTIVE MEDICINE , 52 (5) 379 - 384.
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OBJECTIVE: To perform a pilot study to investigate the relationship between localized, provoked vulvodynia of the vestibule and inflammatory cytokine expression.STUDY DESIGN: Women with a diagnosis of localized, provoked vulvodynia had tissue samples taken for vulvar expression of Interleukin I a and 10 and tumor necrosis factor a and compared to those of a control group.RESULTS: The study group did not show a significant increase in expression of inflammatory markers.CONCLUSION: There was no evidence in this study that localized, provoked vulvodynia is an inflammatory condition, as previously thought. This may be helpful in explaining why some women are resistant to medical or antiinflammatory treatment and may allow treatment to be prescribed more effectively.
|Title:||Is localized, provoked vulvodynia an inflammatory condition?|
|Keywords:||vulvar diseases, vestibule, cytokines, vulvodynia, VULVAR VESTIBULITIS SYNDROME, NERVE-FIBER PROLIFERATION, INTERSTITIAL CYSTITIS, WOMEN, ALPHA|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Women's Health > Maternal and Fetal Medicine
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Women's Health > Women's Cancer
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