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Functional biology of the α <inf>2</inf> δ subunits of voltage-gated calcium channels

Davies, A; Hendrich, J; Van Minh, AT; Wratten, J; Douglas, L; Dolphin, AC; (2007) Functional biology of the α <inf>2</inf> δ subunits of voltage-gated calcium channels. Trends in Pharmacological Sciences , 28 (5) pp. 220-228. 10.1016/j.tips.2007.03.005.

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Abstract

In this review, we examine what is known about the mechanism of action of the auxiliary α 2 δ subunits of voltage-gated Ca 2+ (Ca v ) channels. First, to provide some background on the α 2 δ proteins, we discuss the genes encoding these channels, in addition to the topology and predicted structure of the α 2 δ subunits. We then describe the effects of α 2 δ subunits on the biophysical properties of Ca v channels and their physiological function. All α 2 δ subunits increase the density at the plasma membrane of Ca 2+ channels activated by high voltage, and we discuss what is known about the mechanism underlying this trafficking. Finally, we consider the link between α 2 δ subunits and disease, both in terms of spontaneous and engineered mouse mutants that show cerebellar ataxia and spike-wave epilepsy, and in terms of neuropathic pain and the mechanism of action of the gabapentinoid drugs - small-molecule ligands of the α 2 δ-1 and α 2 δ-2 subunits. © 2007 Elsevier Ltd. All rights reserved.

Type: Article
Title: Functional biology of the α <inf>2</inf> δ subunits of voltage-gated calcium channels
DOI: 10.1016/j.tips.2007.03.005
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/177567
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