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neuroConstruct: A tool for modeling networks of neurons in 3D space

Gleeson, P; Steuber, V; Silver, RA; (2007) neuroConstruct: A tool for modeling networks of neurons in 3D space. NEURON , 54 (2) 219 - 235. 10.1016/j.neuron.2007.03.025. Gold open access

Abstract

Conductance-based neuronal network models can help us understand how synaptic and cellular mechanisms underlie brain function. However, these complex models are difficult to develop and are inaccessible to most neuroscientists. Moreover, even the most biologically realistic network models disregard many 3D anatomical features of the brain. Here, we describe a new software application, neuroConstruct, that facilitates the creation, visualization, and analysis of networks of multicompartmental neurons in 3D space. A graphical user interface allows model generation and modification without programming. Models within neuroConstruct are based on new simulator-in dependent NeuroML standards, allowing automatic generation of code for NEURON or GENESIS simulators. neuroConstruct was tested by reproducing published models and its simulator independence verified by comparing the same model on two simulators. We show how more anatomically realistic network models can be created and their properties compared with experimental measurements by extending a published 1D cerebellar granule cell layer model to 3D.

Type: Article
Title: neuroConstruct: A tool for modeling networks of neurons in 3D space
Open access status: An open access publication
DOI: 10.1016/j.neuron.2007.03.025
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC18859...
Keywords: NEOCORTICAL PYRAMIDAL NEURONS, DENDRITIC MORPHOLOGY, HIPPOCAMPAL-NEURONS, SPIKE INITIATION, SYSTEMS BIOLOGY, NITRIC-OXIDE, IN-VIVO, CELL, SIMULATION, CORTEX
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/177553
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