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Cerebellar LTD and pattern recognition by Purkinje cells

Steuber, V; Mittmann, W; Hoebeek, FE; Silver, RA; De Zeeuw, CI; Hausser, M; De Schutter, E; (2007) Cerebellar LTD and pattern recognition by Purkinje cells. NEURON , 54 (1) 121 - 136. 10.1016/j.neuron.2007.03.015.

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Abstract

Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD. In vivo, we observed longer pauses in LTD-deficient mice. Our results suggest a novel form of neural coding in the cerebellar cortex.

Type: Article
Title: Cerebellar LTD and pattern recognition by Purkinje cells
DOI: 10.1016/j.neuron.2007.03.015
Keywords: LONG-TERM DEPRESSION, ACTIVE MEMBRANE MODEL, KINASE-C INHIBITOR, PARALLEL FIBER LTD, RAT CEREBELLUM, IN-VITRO, BIDIRECTIONAL PLASTICITY, POSTSYNAPTIC POTENTIALS, SYNAPTIC CURRENTS, GRANULE CELL
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/177527
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