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Surgical model to assess the effects and optimal timing of craniofacial fixation

Sims, CD; Butler, PE; Casanova, R; Randolph, MA; Ahn, DK; Yaremchuk, MJ; (1996) Surgical model to assess the effects and optimal timing of craniofacial fixation. J Craniofac.Surg. , 7 (6) 412 - 416.

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Abstract

An in utero swine model of craniofacial deformity was developed as a potential alternative to neonatal models currently used for evaluating the optimal timing and long-term effects of rigid fixation techniques on a growing cranium. At 75% gestation, seven fetal piglets were randomly selected to undergo periosteal stripping of frontal and parietal bone segments with and without extensive coronal suture fusion procedures with cyanoacrylate adhesive. Fetal swine were killed postpartum at 4 and 11 weeks after fusion to assess craniofacial deformity. Piglets undergoing coronal fusion had slight deviation of the nose-snout toward the side of fusion and taller cranial vaults. The vertical cranial index of the experimental fusion group was 0.34 in comparison to a vertical index of 0.27 for the controls, suggesting abnormal vertical height expansion. There was no difference in the horizontal cranial index of either control or experimental fusion groups. Neither sows nor piglets were lost to anesthetic complications, uterine sepsis, or preterm labor during the initial laparotomy or subsequent cesarean delivery

Type:Article
Title:Surgical model to assess the effects and optimal timing of craniofacial fixation
Additional information:DA - 19990520IS - 1049-2275 (Print)LA - engPT - Journal ArticleRN - 0 (Tissue Adhesives)SB - D
Keywords:Animals, complications, Craniosynostoses, Disease Models, Animal, embryology, Facial Asymmetry, Female, Fetus, growth & development, Laparotomy, Pregnancy, Skull, surgery, Swine, Tissue Adhesives
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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