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Facial transplantation: adding to the reconstructive options after severe facial injury and disease

Clarke, A; Butler, PE; (2005) Facial transplantation: adding to the reconstructive options after severe facial injury and disease. Expert Opin.Biol Ther. , 5 (12) 1539 - 1546.

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Abstract

The ability to reconstruct complex facial injuries is still a considerable challenge despite the development of microsurgical techniques. The reconstructive options for conditions such as panfacial burns are severely limited. The result after multiple surgical procedures in this group is often poor in terms of function and cosmesis. Facial transplantation provides a potential solution, but opinion is currently divided about the extent to which the potential benefits to the quality of life can be justified when weighed against the technical, psychological and immunological risks. This paper reviews the current status of the debate and argues that a rigorous research strategy is the only logical basis for countering the ethical objections to a procedure that offers considerable benefits over existing reconstructive options

Type:Article
Title:Facial transplantation: adding to the reconstructive options after severe facial injury and disease
Additional information:DA - 20051201IS - 1744-7682 (Electronic)LA - engPT - Journal ArticlePT - ReviewSB - IM
Keywords:injuries, surgery, blood supply, Burns, ethics, etiology, Face, Facial Injuries, Facial Neoplasms, Facial Transplantation, Humans, immunology, Immunosuppression, injuries, London, methods, physiology, psychology, Quality of Life, Reconstructive Surgical Procedures, Risk, Tissue Transplantation, transplantation, Transplantation, Homologous
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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