Bryclon, L;
Harrison, NA;
Walker, C;
Steptoe, A;
Critchley, HD;
(2008)
Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans.
Biological Psychiatry
, 63
(11)
1022 - 1029.
10.1016/j.biopsych.2007.12.007.
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Abstract
Background: Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain.Methods: We used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design.Results: Vaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra.Conclusions: Our findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, specifically implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
Type: | Article |
---|---|
Title: | Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.biopsych.2007.12.007 |
Publisher version: | http://dx.doi.org/10.1016/j.biopsych.2007.12.007 |
Language: | English |
Additional information: | An open access Elsevier publication |
Keywords: | Cytokines, fMRI, peripheral inflammation, psychomotor slowing, substantia nigra, sickness behavior, interferon-alpha, parkinsons-disease, rat-brain, dopamine, activation, interleukin-6, cytokines, system, fever |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/177164 |
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