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c-Jun is a negative regulator of myelination

Parkinson, DB; Bhaskaran, A; Arthur-Farraj, P; Noon, LA; Woodhoo, A; Lloyd, AC; ... Jessen, KR; + view all (2008) c-Jun is a negative regulator of myelination. J CELL BIOL , 181 (4) 625 - 637. 10.1083/jcb.200803013. Gold open access

Abstract

Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription factors that are activated by axonal signals and control the generation of myelin-forming cells. Myelin-forming cells remain remarkably plastic and can revert to the immature phenotype, a process which is seen in injured nerves and demyelinating neuropathies. We report that c-Jun is an important regulator of this plasticity. At physiological levels, c-Jun inhibits myelin gene activation by Krox-20 or cyclic adenosine monophosphate. c-Jun also drives myelinating cells back to the immature state in transected nerves in vivo. Enforced c-Jun expression inhibits myelination in cocultures. Furthermore, c-Jun and Krox-20 show a cross-antagonistic functional relationship. c-Jun therefore negatively regulates the myelinating Schwann cell phenotype, representing a signal that functionally stands in opposition to the promyelin transcription factors. Negative regulation of myelination is likely to have significant implications for three areas of Schwann cell biology: the molecular analysis of plasticity, demyelinating pathologies, and the response of peripheral nerves to injury.

Type:Article
Title:c-Jun is a negative regulator of myelination
Open access status:An open access publication
DOI:10.1083/jcb.200803013
Publisher version:http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2386103/?tool=pubmed
Keywords:SCHWANN-CELL MYELINATION, PERIPHERAL NERVOUS-SYSTEM, WALLERIAN DEGENERATION, MACROPHAGE RECRUITMENT, GENE-EXPRESSION, GLIAL-CELLS, IN-VITRO, NERVES, PROLIFERATION, DIFFERENTIATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology

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