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Obesity and type 2 diabetes risk in midadult life: The role of childhood adversity

Thomas, C; Hypponen, E; Power, C; (2008) Obesity and type 2 diabetes risk in midadult life: The role of childhood adversity. PEDIATRICS , 121 (5) E1240 - E1249. 10.1542/peds.2007-2403.

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Abstract

OBJECTIVE. Child abuse has been associated with poorer physical health in adulthood, but less is known about childhood adversity more broadly, including neglect and family problems, or the pathways from adversity to adult disease. We have examined how different stressful emotional or neglectful childhood adversities are related to adiposity and glucose control in midadulthood, taking into account childhood factors, and whether the relationships are mediated by adult health behaviors and socioeconomic position.METHODS. This was a prospective longitudinal study of 9310 members of the 1958 British birth cohort who participated in a biomedical interview at 45 years of age. Primary outcomes consisted of continuous measures of BMI, waist circumference, and glycosylated hemoglobin at 45 years and categorical indicators: total obesity (BMI >= 30), central obesity (waist circumference: >= 102 cm for men and >= 88 cm for women), and glycosylated hemoglobin level of >= 6.RESULTS. The risk of obesity increased by 20% to 50% for several adversities (physical abuse, verbal abuse, witnessed abuse, humiliation, neglect, strict upbringing, physical punishment, conflict or tension, low parental aspirations or interest in education, hardly takes outings with parents, and father hardly reads to child). Adversities with the strongest associations with adiposity (eg, physical abuse) tended to be associated with glycosylated hemoglobin levels of >= 6, but in most cases associations were explained by adjustment for adulthood mediators such as adiposity. Effects of other adversities reflecting less severe emotional neglect and family environment were largely explained by childhood socioeconomic factors.CONCLUSIONS. Some childhood adversities increase the risk of obesity in adulthood and thereby increase the risk for type 2 diabetes. Research is needed to understand the interrelatedness of adversities, the social context of their occurrence, and trajectories from adversity to adult disease.

Type: Article
Title: Obesity and type 2 diabetes risk in midadult life: The role of childhood adversity
DOI: 10.1542/peds.2007-2403
Keywords: type 2 diabetes, HbA1c, obesity, child abuse, child neglect, lifestyle, socioeconomic factors, smoking, alcohol drinking, cohort studies, BRITISH BIRTH COHORT, SEXUAL-ABUSE, RETROSPECTIVE FINDINGS, HOUSEHOLD DYSFUNCTION, SOCIOECONOMIC-STATUS, GLYCATED HEMOGLOBIN, ALCOHOL-CONSUMPTION, CIGARETTE-SMOKING, YOUNG ADULTHOOD, EXPERIENCES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/176947
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