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Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing

Sarri, M; Greenwood, R; Kalra, L; Papps, B; Husain, M; Driver, J; (2008) Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing. NEUROPSYCHOLOGIA , 46 (4) 1069 - 1080. 10.1016/j.neuropsychologia.2007.11.005. Gold open access

Abstract

Prism adaptation to rightward optical shifts during visually guided pointing is considered a promising intervention in right-hemi sphere stroke patients with left spatial neglect. Conventionally, prism adaptation is assessed via aftereffects, on subjective straight ahead (SSA) pointing with eyes closed; or by visual open-loop pointing (VOL), i.e. pointing to a visual target without seeing the hand. Previous data suggest indirectly that prism aftereffects in neglect patients may be larger (pathologically so) when assessed by SSA than by VOL. But these measures have never been directly compared within the same patients after identical prism exposure. Accordingly we implemented both measures here within the same group of 13 neglect patients and 13 controls. Prism aftereffects were much larger for SSA than VOL in neglect patients, falling outside the normative range only for SSA. This may arise because the SSA task can itself involve aspects of neglect that may be ameliorated by the prism intervention, hence showing abnormal changes after prisms. The extent of SSA change after prisms varied between patients, and correlated with improvements on a standard cancellation measure for neglect. The lesions of patients who did versus did not show neglect improvement immediately after prisms provide an initial indication that lack of improvement may potentially relate to cortical damage in right intraparietal sulcus and white matter damage in inferior parietal lobe and middle frontal gyrus. Future studies of possible rehabilitative impact from prisms upon neglect may need to consider carefully how to measure prism adaptation per se, separately from any impact of such adaptation upon manifestations of neglect. (c) 2007 Elsevier Ltd. All rights reserved.

Type:Article
Title:Prism adaptation aftereffects in stroke patients with spatial neglect: Pathological effects on subjective straight ahead but not visual open-loop pointing
Open access status:An open access publication
DOI:10.1016/j.neuropsychologia.2007.11.005
Publisher version:http://ukpmc.ac.uk/abstract/MED/18083203
Keywords:neglect, prism adaptation, straight ahead pointing, cancellation, rehabilitation, lesion anatomy, POSTERIOR PARIETAL CORTEX, LEFT UNILATERAL NEGLECT, EGOCENTRIC REFERENCE, HEMISPATIAL NEGLECT, VISUOSPATIAL NEGLECT, SPACE REPRESENTATION, ATTENTION DEFICITS, BODY ORIENTATION, LINE BISECTION, DEVIATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health

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