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REGIONAL CHANGES IN CEREBRAL HEMODYNAMICS AS A RESULT OF A VISUAL STIMULUS MEASURED BY NEAR-INFRARED SPECTROSCOPY

MEEK, JH; ELWELL, CE; KHAN, MJ; ROMAYA, J; WYATT, JS; DELPY, DT; ZEKI, S; (1995) REGIONAL CHANGES IN CEREBRAL HEMODYNAMICS AS A RESULT OF A VISUAL STIMULUS MEASURED BY NEAR-INFRARED SPECTROSCOPY. P ROY SOC LOND B BIO , 261 (1362) 351 - 356.

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Abstract

Near infrared spectroscopy (NIRS) is used to measure global changes in cerebral haemodynamics. We have adapted the technique to measure regional changes in response to a visual stimulus. Ten volunteers were exposed to a computer generated visual stimulus designed to activate a large area of the visual cortex, including V1, V2, V3, V4 and V5. The stimulus was on for 30 s and off for 30 s. Changes in the concentrations of oxyhaemoglobin ([HbO(2)]) and deoxyhaemoglobin ([Hb]) were measured using a commercial spectrometer (NIRO500), over the occipital cortex. The data were summed over ten cycles. As a control, the experiment was repeated over the frontal cortex. For each subject [HbO(2)] increased during stimulation, and decreased when the stimulus was off. The mean (+/-s.e.m.) change in [HbO(2)] was 0.54 +/- 0.14 mu mol l(-1). The change in total haemoglobin concentration, given by [HbO(2)] + [Hb] was 0.61 +/- 0.21 mu mol l(-1), equivalent to a rise in cerebral blood volume of 0.04 +/- 0.01 ml 100 g(-1) which is about 2% of the total cerebral blood volume. There was no significant change in [HbO(2)] over the frontal cortex, implying that the changes in blood volume originated in the occipital lobe. This demonstrates that NIRS provides a non-invasive method of measuring regional changes in cerebral haemodynamics as a result of visual stimulation.

Type:Article
Title:REGIONAL CHANGES IN CEREBRAL HEMODYNAMICS AS A RESULT OF A VISUAL STIMULUS MEASURED BY NEAR-INFRARED SPECTROSCOPY
Keywords:POSITRON EMISSION TOMOGRAPHY, HUMAN BRAIN ACTIVITY, FUNCTIONAL SPECIALIZATION, SENSORY STIMULATION, NEWBORN-INFANTS, CORTEX, OXYGENATION, TISSUE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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