UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Pattern-specific role of the current orientation used to deliver Theta Burst Stimulation

Talelli, P; Cheeran, BJ; Teo, JTH; Rothwell, JC; (2007) Pattern-specific role of the current orientation used to deliver Theta Burst Stimulation. CLIN NEUROPHYSIOL , 118 (8) 1815 - 1823. 10.1016/j.clinph.2007.05.062.

Full text not available from this repository.

Abstract

Objective: To evaluate the role of current direction on the after-effects of Theta Burst Stimulation (TBS) delivered with a biphasic Magstim 2002 stimulator.Methods: Inhibitory (cTBS) and excitatory TBS (iTBS) were delivered over the motor cortex of healthy individuals using reversed and standard current orientations (initial current in the antero-posterior direction) at 80% and 100% of their respective active motor thresholds (AMT). The after-effects on the MEP amplitude were measured for 25 min. The effects of the most effective reversed cTBS paradigm on intracortical inhibition (SICI) and facilitation (ICF) were also tested.Results: Reversing the current direction reduced ANIT by 26% +/- 2%. Compared to standard cTBS, reversed cTBS induced stronger and longer-lasting inhibition of corticospinal excitability when delivered at 100% AMT(rev). SICI was reduced after cTBS(100%revAMT) while ICF was unchanged. The after-effects of reversed iTBS were quite variable regardless of the intensity.Conclusions: cTBS applied with antero-posterior current is more effective in suppressing subsequent MEPs than conventionally orientated cTBS when the absolute stimulation intensity is similar. On the contrary, posterior current orientation reduces the efficacy of iTBS.Significance: The current direction may affect the power of inhibitory and excitatory TBS in opposite ways; this should be considered in order to optimise the after-effects of biphasic RTMS. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Pattern-specific role of the current orientation used to deliver Theta Burst Stimulation
DOI: 10.1016/j.clinph.2007.05.062
Keywords: repetitive transcranial magnetic stimulation, theta burst stimulation, biphasic pulses, I-waves, inhibition, facilitation, TRANSCRANIAL MAGNETIC STIMULATION, HUMAN MOTOR CORTEX, CORTICAL EXCITABILITY, I WAVES, COIL, INHIBITION, RTMS, FACILITATION, INTENSITY, HUMANS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/176567
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item