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Neural coding of tactile decisions in the human prefrontal cortex

Pleger, B; Ruff, CC; Blankenburg, F; Bestmann, S; Wiech, K; Stephan, KE; ... Dolan, RJ; + view all (2006) Neural coding of tactile decisions in the human prefrontal cortex. J NEUROSCI , 26 (48) 12596 - 12601. 10.1523/JNEUROSCI.4275-06.2006. Gold open access

Abstract

The neural processes underlying tactile decisions in the human brain remain elusive. We addressed this question in a functional magnetic resonance imaging study using a somatosensory discrimination task, requiring participants to compare the frequency of two successive tactile stimuli. Tactile stimuli per se engaged somatosensory, parietal, and frontal cortical regions. Using a statistical model that accounted for the relative difference in frequencies (i.e., Weber fraction) and discrimination accuracy (i.e., correct or incorrect), we show that trial-by-trial relative frequency difference is represented linearly by activity changes in the left dorsolateral prefrontal cortex (DLPFC), the dorsal anterior cingulate cortex, and bilateral anterior insular cortices. However, a circumscribed region within the left DLPFC showed a different response pattern expressed as activity changes that were monotonically related to relative stimulation difference only for correct but not for incorrect trials. Our findings suggest that activity in the left DLPFC encodes stimulus representations that underlie veridical tactile decisions in humans.

Type:Article
Title:Neural coding of tactile decisions in the human prefrontal cortex
Open access status:An open access publication
DOI:10.1523/JNEUROSCI.4275-06.2006
Publisher version:http://ukpmc.ac.uk/abstract/MED/17135421
Keywords:tactile decision, tactile discrimination, Weber fraction, somatosensory cortex, dorsolateral prefrontal cortex, functional magnetic resonance imaging, ANTERIOR CINGULATE CORTEX, MEDIAL FRONTAL-CORTEX, PERCEPTUAL DECISION, SOMATOSENSORY CORTEX, HUMAN BRAIN, PHYSIOLOGICAL CONDITION, CORTICAL CONNECTIONS, SENSORY STIMULI, PREMOTOR CORTEX, PARIETAL CORTEX
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Motor Neuroscience and Movement Disorders
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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