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Abnormal brain connectivity in first-episode psychosis: A diffusion MRI tractography study of the corpus callosum

Price, G; Cercignani, M; Parker, GJM; Altmann, DR; Barnes, TRE; Barker, GJ; Joyce, EM; (2007) Abnormal brain connectivity in first-episode psychosis: A diffusion MRI tractography study of the corpus callosum. Neuroimage , 35 (2) 458 - 466. 10.1016/j.neuroimage.2006.12.019. Green open access

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Abstract

A model of disconnectivity involving abnormalities in the cortex and connecting white matter pathways may explain the clinical manifestations of schizophrenia. Recently, diffusion imaging tractography has made it possible to study white matter pathways in detail and we present here a study of patients with first-episode psychosis using this technique. We selected the corpus callosum for this study because there is evidence that it is abnormal in schizophrenia. In addition, the topographical organization of its fibers makes it possible to relate focal abnormalities to specific cortical regions. Eighteen patients with first-episode psychosis and 21 healthy subjects took part in the study. A probabilistic tractography algorithm (PICo) was used to study fractional anisotropy (FA). Seed regions were placed in the genu and splenium to track fiber tracts traversing these regions, and a multi-threshold approach to study the probability of connection was used. Multiple linear regressions were used to explore group differences. FA, a measure of tract coherence, was reduced in tracts crossing the genu, and to a lesser degree the splenium, in patients compared with controls. FA was also lower in the germ in females across both groups, but there was no gender-by-group interaction. The FA reduction in patients may be due to aberrant myelination or axonal abnormalities, but the similar tract volumes in the two groups suggest that severe axonal loss is unlikely at this stage of the illness.

Type: Article
Title: Abnormal brain connectivity in first-episode psychosis: A diffusion MRI tractography study of the corpus callosum
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroimage.2006.12.019
Publisher version: http://dx.doi.org/10.1016/j.neuroimage.2006.12.019
Language: English
Additional information: An open access publication from Elsevier.
Keywords: Corpus callosum, Diffusion tensor imaging, First-episode psychosis, Tractography, White-matter integrity, Bipolar disorder, Onset schizophrenia, 1st episode, Neuropathological abnormalities, Fiber composition, Rating-scale, Postmortem, Gender, System
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/175943
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