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The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle

Ates, K; Yang, SY; Orrell, RW; Sinanan, ACM; Simons, P; Solomon, A; ... Lewis, MP; + view all (2007) The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle. FEBS LETT , 581 (14) 2727 - 2732. 10.1016/j.febslet.2007.05.030.

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Abstract

The effects of muscle splice variants of insulin-like growth factor I (IGF-I) on proliferation and differentiation were studied in human primary muscle cell cultures from healthy subjects as well as from muscular dystrophy and ALS patients. Although the initial numbers of mononucleated progenitor cells expressing desmin were lower in diseased muscle, the E domain peptide of IGF-IEc (MGF) significantly increased the numbers of progenitor cells in healthy and diseased muscle. IGF-I significantly enhances myogenic differentiation whereas MGF E peptide blocks this pathway, resulting in an increased progenitor (stem) cell pool and thus potentially facilitating repair and maintenance of this postmitotic tissue. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Type:Article
Title:The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle
DOI:10.1016/j.febslet.2007.05.030
Keywords:muscle stem, satellite cells, ALS, muscular dystrophy, insulin-like growth factor I, mechano growth factor, GROWTH-FACTOR, STEM-CELL, POSTNATAL MYOGENESIS, SATELLITE CELL, PEPTIDE, ACTIVATION, DIFFERENTIATION, EXPRESSION, HORMONE, DOMAIN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Clinical Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Inflammation
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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