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Detecting latency differences in event-related BOLD responses: Application to words versus nonwords and initial versus repeated face presentations

Henson, RNA; Price, CJ; Rugg, MD; Turner, R; Friston, KJ; (2002) Detecting latency differences in event-related BOLD responses: Application to words versus nonwords and initial versus repeated face presentations. NEUROIMAGE , 15 (1) 83 - 97. 10.1006/nimg.2001.0940.

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Abstract

We introduce a new method for detecting differences in the latency of blood oxygenation level-dependent (BOLD) responses to brief events within the context of the General Linear Model. Using a first-order Taylor approximation in terms of the temporal derivative of a canonical hemodynamic response function, statistical parametric maps of differential latencies were estimated via the ratio of derivative to canonical parameter estimates. This method was applied to two example datasets: comparison of words versus nonwords in a lexical decision task and initial versus repeated presentations of faces in a fame judgment task. Tests across subjects revealed both magnitude and latency differences within several brain regions. This approach offers a computationally efficient means of detecting BOLD latency differences over the whole brain. Precise characterization of the hemodynamic latency and its interpretation in terms of underlying neural differences remain problematic, however. (C) 2002 Elsevier Science.

Type:Article
Title:Detecting latency differences in event-related BOLD responses: Application to words versus nonwords and initial versus repeated face presentations
DOI:10.1006/nimg.2001.0940
Keywords:event-related, fMRI, word, nonword, faces, BOLD, impulse, latency, deactivations, FUNCTIONAL MRI, HEMODYNAMIC-RESPONSE, SEMANTIC SYSTEM, BRAIN ACTIVITY, RECOGNITION, FMRI, ANATOMY, EXTRASTRIATE, PSEUDOWORDS, MECHANISMS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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