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Differential encoding of losses and gains in the human striatum

Seymour, B; Daw, N; Dayan, P; Singer, T; Dolan, R; (2007) Differential encoding of losses and gains in the human striatum. J NEUROSCI , 27 (18) 4826 - 4831. 10.1523/JNEUROSCI.0400-07.2007. Gold open access

Abstract

Studies on human monetary prediction and decision making emphasize the role of the striatum in encoding prediction errors for financial reward. However, less is known about how the brain encodes financial loss. Using Pavlovian conditioning of visual cues to outcomes that simultaneously incorporate the chance of financial reward and loss, we show that striatal activation reflects positively signed prediction errors for both. Furthermore, we show functional segregation within the striatum, with more anterior regions showing relative selectivity for rewards and more posterior regions for losses. These findings mirror the anteroposterior valence-specific gradient reported in rodents and endorse the role of the striatum in aversive motivational learning about financial losses, illustrating functional and anatomical consistencies with primary aversive outcomes such as pain.

Type:Article
Title:Differential encoding of losses and gains in the human striatum
Open access status:An open access publication
DOI:10.1523/JNEUROSCI.0400-07.2007
Publisher version:http://ukpmc.ac.uk/abstract/MED/17475790
Keywords:basal ganglia, classical conditioning, reinforcement learning, neuroeconomics, opponent process, decision making, NUCLEUS-ACCUMBENS NEURONS, REWARD PREDICTION, VENTRAL STRIATUM, DOPAMINE NEURONS, HUMAN BRAIN, SHELL, STIMULI, FEAR, RESPONSES, BEHAVIOR
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neuroscience Unit

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