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Recipient Damage After Musculocutaneous Transplant Rejection

Horner, BM; Eberlin, KR; Ferguson, KK; Hirsh, EL; Randolph, MA; Butler, PEM; (2008) Recipient Damage After Musculocutaneous Transplant Rejection. TRANSPLANTATION , 86 (8) 1104 - 1110. 10.1097/TP.0b013e3181872ac3.

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Abstract

Background. In the event of a composite allograft failure, damage to the recipient tissues may make retransplantation impossible. This study aimed to quantify the damage after composite allograft failure to assess whether retransplantation is feasible.Methods. Rats (n=6) in the group I received composite musculocutaneous flap allotransplants (WF-Lew) with immunosuppression allowing healing-in of the allograft before being tapered allowing rejection. At full rejection, the recipient vascular pedicle was examined, biopsies of the recipient tissue bed were taken and graded for damage, and in vitro assays were performed. Groups II (allograft without immunosuppression, n=7), III (isograft with immunosuppression, n=5), and IV (isograft without inummosuppression, n=6) were included to attempt to identify the contributions of the rejection process, inummosuppression, and healing to recipient tissue damage.Results. The vascular pedicle was patent to within 1 mm of the anastomosis in all rejected allografts. Furthermore, it was possible to retransplant after full rejection. There was minimal damage to the recipient tissues at the time of full rejection in group I. In contrast, group II had significantly more damage (P < 0.05) to recipient muscle and skin. This correlated with more severe immune reaction with more than 100 times antibody production in group II compared with group I. Groups III and IV had little recipient tissue damage.Conclusions. These results suggest that it is possible to retransplant after rejection of a musculocutaneous transplant while on immunosuppression. Furthermore, the second transplant will not be limited in form or function by recipient tissue bed damage.

Type:Article
Title:Recipient Damage After Musculocutaneous Transplant Rejection
DOI:10.1097/TP.0b013e3181872ac3
Keywords:Composite, Tissue, Retransplantation, Recipient, Damage, COMPOSITE TISSUE-TRANSPLANTATION, PRIMARY ALLOGRAFT NEPHRECTOMY, INTERNATIONAL REGISTRY, HAND, RATS, CYCLOSPORINE, TOLERANCE, FK-506
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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