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Plastic surgical delivery systems for targeted gene therapy

Ghali, S; Dempsey, MP; Jones, DM; Grogan, RH; Butler, PE; Gurtner, GC; (2008) Plastic surgical delivery systems for targeted gene therapy. Annals of Plastic Surgery , 60 (3) 323 - 332.

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Abstract

The expansion of gene therapy applications from inherited disorders to acquired conditions has been mirrored by an exponential rise in both experimental work and clinical trials. This review highlights current plastic surgical delivery systems and clinical applications for targeted gene therapy. We revisit some of the vectors used both experimentally and in clinical gene therapy trials, with an emphasis on developments in plastic surgical delivery systems resulting in improved targeting of therapeutic genes. In addition, we discuss a novel technique, for the delivery of gene therapy Using the ex vivo transduction of free flaps, developed in our laboratory. This delivery system achieves targeted high-level transgene expression with minimal demonstrable systemic toxicity. Advances in delivery systems are essential for translating basic research into clinical therapeutics

Type:Article
Title:Plastic surgical delivery systems for targeted gene therapy
Additional information:WoS ID: 000253430300017 Times Cited: 1ReviewEnglishGurtner, G. CStanford Univ, PSRL, 257 Campus Dr,GK-201, Stanford, CA 94305 USACited References Count: 104266JELIPPINCOTT WILLIAMS & WILKINS530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USAPHILADELPHIA
Keywords:ADENOASSOCIATED VIRUS, ADENOVIRUS VECTORS, BONE-MARROW, delivery systems, ENDOTHELIAL PROGENITOR CELLS, IMMUNE-RESPONSES, IN-VIVO ELECTROPORATION, microvascular free flaps, NECK-CANCER, PHASE-I, POSTNATAL VASCULOGENESIS, SIMPLEX VIRUS VECTORS, targeted gene therapy
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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