Duzel, E; Bunzeck, N; Guitart-Masip, M; Duzel, S; (2010) NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging. NEUROSCI BIOBEHAV R , 34 (5) 660 - 669. 10.1016/j.neubiorev.2009.08.006.
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Studies in humans and animals show that dopaminergic neuromodulation originating from the substantia nigra/ventral tegmental area (SN/VTA) of the midbrain enhances hippocampal synaptic plasticity for novel events and has a motivationally energizing effect on actions through striatal mechanisms. In this review, we discuss how these mechanisms of dopaminergic neuromodulation connect to the behavioural and functional consequences that age-related structural degeneration of the SN/VTA exerts on declarative memory. We propose a framework called 'Novelty-related Motivation of Anticipation and exploration by Dopamine' (NOMAD) which captures existing links between novelty, dopamine, long-term memory, plasticity, energization and their relation to aging. We propose that maximizing the use of this mechanism by maintaining mobility and exploration of novel environments could be a potential mechanism to slow age-related decline of memory. (C) 2009 Elsevier Ltd. All rights reserved.
|Title:||NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging|
|Keywords:||Substantia nigra/VTA, Novelty, Aging, Dopamine, Hippocampus, Motivation, Memory, Consolidation, MILD COGNITIVE IMPAIRMENT, VENTRAL TEGMENTAL AREA, LONG-TERM POTENTIATION, SUBSTANTIA-NIGRA, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, HUMAN-BRAIN, REWARD ANTICIPATION, ADULT NEUROGENESIS, NEURAL MECHANISMS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
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