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Inferior Frontal Gyrus Activation Predicts Individual Differences in Perceptual Learning of Cochlear-Implant Simulations

Eisner, F; McGettigan, C; Faulkner, A; Rosen, S; Scott, SK; (2010) Inferior Frontal Gyrus Activation Predicts Individual Differences in Perceptual Learning of Cochlear-Implant Simulations. J NEUROSCI , 30 (21) 7179 - 7186. 10.1523/JNEUROSCI.4040-09.2010. Gold open access

Abstract

This study investigated the neural plasticity associated with perceptual learning of a cochlear implant (CI) simulation. Normal-hearing listeners were trained with vocoded and spectrally shifted speech simulating a CI while cortical responses were measured with functional magnetic resonance imaging (fMRI). A condition in which the vocoded speech was spectrally inverted provided a control for learnability and adaptation. Behavioral measures showed considerable individual variability both in the ability to learn to understand the degraded speech, and in phonological working memory capacity. Neurally, left-lateralized regions in superior temporal sulcus and inferior frontal gyrus (IFG) were sensitive to the learnability of the simulations, but only the activity in prefrontal cortex correlated with interindividual variation in intelligibility scores and phonological working memory. A region in left angular gyrus (AG) showed an activation pattern that reflected learning over the course of the experiment, and covariation of activity in AG and IFG was modulated by the learnability of the stimuli. These results suggest that variation in listeners' ability to adjust to vocoded and spectrally shifted speech is partly reflected in differences in the recruitment of higher-level language processes in prefrontal cortex, and that this variability may further depend on functional links between the left inferior frontal gyrus and angular gyrus. Differences in the engagement of left inferior prefrontal cortex, and its covariation with posterior parietal areas, may thus underlie some of the variation in speech perception skills that have been observed in clinical populations of CI users.

Type:Article
Title:Inferior Frontal Gyrus Activation Predicts Individual Differences in Perceptual Learning of Cochlear-Implant Simulations
Open access status:An open access publication
DOI:10.1523/JNEUROSCI.4040-09.2010
Publisher version:http://ukpmc.ac.uk/abstract/MED/20505085
Keywords:NORMAL-HEARING SUBJECTS, NOISE-VOCODED SPEECH, EVENT-RELATED FMRI, WORKING-MEMORY, SEMANTIC AMBIGUITY, WORD RECOGNITION, AUDITORY-CORTEX, COMPREHENSION, BRAIN, CHILDREN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Speech, Hearing and Phonetic Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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