Charakida, M and Loukogeorgakis, SP and Okorie, MI and Masi, S and Halcox, JP and Deanfield, JE and Klein, NJ (2009) Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy. ANTIVIR THER , 14 (8) 1075 - 1079. 10.3851/IMP1437.
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Background: Recent evidence suggests that both the HIV virus and antiretroviral therapy (ART) are associated with premature atherosclerosis in adults. Increased arterial stiffness as assessed by pulse wave velocity (PWV) has been associated with adverse cardiovascular outcome in adults. The relationship between HIV infection and treatment and arterial stiffness has not been evaluated in children.Methods: We studied 83 HIV-infected children with a mean +/- SD age of 11.0 +/- 3.1 years and 59 controls aged 12.2 +/- 2.8 years. Among the HIV-infected children, 48 were receiving ART (23 including a protease inhibitor). Arterial stiffness was assessed non-invasively by carotid-radial PWV. Disease severity was defined according to the CDC classification.Results: PWV was significantly increased in HIV-infected children compared with controls (P<0.05). A significant association between age and PWV was noted in HIV-infected children but not in controls. HIV-infected children receiving ART had significantly increased total cholesterol levels and PWV compared with non-treated children (P<0.001 and P<0.05, respectively). CDC stage was greater in ART-treated compared with non-treated HIV-infected children (P<0.001). No differences in other cardiovascular risk factors were noted in the two groups. After multivariable analysis, ART, systolic blood pressure, disease severity and total cholesterol remained independent predictors of PWV.Conclusions: HIV-infected children have increased arterial stiffness compared with healthy children. These changes were more pronounced with increasing age in HIV-infected children particularly in those who were receiving ART.
|Title:||Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy|
|Keywords:||IMMUNODEFICIENCY-VIRUS-INFECTION, AORTIC STIFFNESS, BLOOD-PRESSURE, ADULT PATIENTS, IMPACT, OUTCOMES, DISEASE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Cardiorespiratory Sciences > ICH - Cardiac Unit|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Infection and Immunity > ICH - Immunobiology Unit
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Infection and Immunity > ICH - Infectious Diseases and Microbiology
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