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STN stimulation alters pallidal-frontal coupling during response selection under competition

Thobois, S; Hotton, GR; Pinto, S; Wilkinson, L; Limousin-Dowsey, P; Brooks, DJ; Jahanshahi, M; (2007) STN stimulation alters pallidal-frontal coupling during response selection under competition. J CEREBR BLOOD F MET , 27 (6) 1173 - 1184. 10.1038/sj.jcbfm..9600425.

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Abstract

To investigate the effects of bilateral subthalamic nucleus (STN) stimulation on patterns of brain activation during random number generation (RNG), a task that requires suppression of habitual counting and response selection under competition. We used (H2O)-O-15 positron emission tomography to investigate the changes of regional cerebral blood flow (rCBF) induced by bilateral STN stimulation during a RNG task, in six patients with Parkinson's disease. Paced RNG at 1Hz was compared with a control counting task. Both tasks were performed off medication with deep brain stimulation on and off. Subthalamic nucleus stimulation had a negative effect on performance of fast-paced RNG, leading to reduced randomness and increased habitual counting. Subthalamic nucleus stimulation also induced a reduction of rCBF in the left dorsal frontal gyrus, inferior frontal gyrus, dorsolateral prefrontal cortex, posterior and right anterior cingulate, and an increase of rCBF in the right internal globus pallidum (GPi) during RNG. Stimulation of the STN significantly altered pallidal coupling with frontal and temporal areas compared with when the stimulators were off. In conclusion, during RNG: (i) STN stimulation activates its output neurons to the GPi; (ii) STN stimulation induces increased inhibition of a prefrontal-cingulate network. This is the first direct evidence that STN stimulation significantly alters pallidal coupling with prefrontal, cingulate, and temporal cortices during performance of a task that requires response selection under competition.

Type: Article
Title: STN stimulation alters pallidal-frontal coupling during response selection under competition
DOI: 10.1038/sj.jcbfm..9600425
Keywords: Parkinson's disease, deep brain stimulation, subthalamic nucleus, random number generation, PET, cognition, SUBTHALAMIC NUCLEUS STIMULATION, TRANSCRANIAL MAGNETIC STIMULATION, DORSOLATERAL PREFRONTAL CORTEX, RANDOM NUMBER GENERATION, DEEP BRAIN-STIMULATION, POSITRON-EMISSION-TOMOGRAPHY, ANTERIOR CINGULATE CORTEX, PARKINSONS-DISEASE, BASAL GANGLIA, EXECUTIVE FUNCTIONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/174554
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