Riordan, SM and Williams, R (2010) Liver: Management of non-acetaminophen-induced ALF. Nature Reviews Gastroenterology and Hepatology , 7 (2) 75 - 77. 10.1038/nrgastro.2009.236.
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Acetylcysteine, a glutathione precursor that detoxifies the reactive metabolite of acetaminophen and replenishes hepatic glutathione stores, is a highly effective treatment for the prevention of acute liver failure (ALF) caused by acetaminophen hepatotoxicity if given within 10 h of an overdose.1 However, treatment with acetylcysteine is less effective if given more than 10 h after an overdose and may not reduce the severity of liver damage if given more than 15 h after an overdose.
|Title:||Liver: Management of non-acetaminophen-induced ALF|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Institute of Hepatology|
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