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A Framework for Using Diffusion Weighted Imaging to Improve Cortical Parcellation

Clarkson, MJ; Malone, IB; Modat, M; Leung, KK; Ryan, N; Alexander, DC; ... Ourselin, S; + view all (2010) A Framework for Using Diffusion Weighted Imaging to Improve Cortical Parcellation. In: Jiang, T and Navab, N and Pluim, JPW and Viegever, MA, (eds.) MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2010, PT I. (pp. 534 - 541). SPRINGER-VERLAG BERLIN

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Abstract

Cortical parcellation refers to anatomical labelling of every point in the cortex. An accurate parcellation is useful in many analysis techniques including the study of regional changes in cortical thickness or volume in ageing and neurodegeneration. Parcellation is also key to anatomic apportioning of functional imaging changes. We present preliminary work on a novel algorithm that takes an entire cortical parcellation and iteratively updates it to better match connectivity information derived from diffusion weighted imaging. We demonstrate the algorithm on a cohort of 17 healthy controls. Initial results show the algorithm recovering artificially induced mis-registrations of the parcellation and also converging to a group-wise average. This work introduces a framework to investigate the relationship between structure and function, with no a-priori knowledge of specific regions of interest.

Type:Proceedings paper
Title:A Framework for Using Diffusion Weighted Imaging to Improve Cortical Parcellation
Event:13th International Conference on Medical Image Computing and Computer-Assisted Intervention
Location:China Natl Convent Ctr, Beijing, PEOPLES R CHINA
Dates:2010-09-20 - 2010-09-24
ISBN-13:978-3-642-15704-2
Keywords:HUMAN CEREBRAL-CORTEX, SURFACE, MRI
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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