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Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules

Donoghue, HD; (2009) Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules. MICROBES INFECT , 11 (14-15) 1156 - 1162. 10.1016/j.micinf.2009.08.008. Green open access

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Abstract

Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term coexistence of host and pathogen. Direct detection and characterisation of ancient microbial DNA and lipid biomarkers confirms palaeopathological diagnoses. Archaeological Mycobacterium tuberculosis resembles extant lineages indicating the timescale for evolutionary changes is considerably longer than originally believed. (C) 2009 Elsevier Masson SAS. All rights reserved.

Type:Article
Title:Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules
Open access status:An open access version is available from UCL Discovery
DOI:10.1016/j.micinf.2009.08.008
Keywords:Ancient DNA, Lipid biomarkers, Mycobacterium tuberculosis, Palaeogenetics, Palaeomicrobiology, POLYMERASE-CHAIN-REACTION, MYCOBACTERIUM-TUBERCULOSIS, BRIEF COMMUNICATION, MOLECULAR ANALYSIS, HUMAN REMAINS, COMPLEX DNA, IRON-AGE, EPIDEMIOLOGY, EVOLUTIONARY, POPULATIONS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of)

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