UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Cytomegalovirus: the role of CMV post-haematopoietic stem cell transplantation

Peggs, KS; Mackinnon, S; (2004) Cytomegalovirus: the role of CMV post-haematopoietic stem cell transplantation. INT J BIOCHEM CELL B , 36 (4) 695 - 701. 10.1016/j.biocel.2003.08.008.

Full text not available from this repository.

Abstract

Human cytomegalovirus (HCMV) is a large DNA virus that is well equipped to evade host immune responses and able to establish lifelong latency. It is able to modulate both innate and adaptive immune reactivity, and has multiple effects on the cell cycle and apoptosis. It is a major opportunistic pathogen in immunocompromised hosts. Reactivation of latent virus may re-stimulate memory T-cell responses that are sufficient to re-establish control over viral replication if the degree of immune suppression is not too great. Following allogeneic transplantation immune responses are often inadequate resulting in progressive tissue damage manifesting as overt HCMV disease that usually presents as pneumonitis, colitis or hepatitis. Currently available antiviral pharmacotherapies are limited by toxicities and lack of efficacy in established HCMV disease. Efforts have therefore focused on molecular diagnostic surveillance protocols that allow earlier intervention, and the development of adoptive immunotherapeutic strategies to hasten host immune reconstitution. (C) 2003 Elsevier Ltd. All rights reserved.

Type: Article
Title: Cytomegalovirus: the role of CMV post-haematopoietic stem cell transplantation
DOI: 10.1016/j.biocel.2003.08.008
Keywords: cytomegalovirus, transplantation, cellular therapy, BONE-MARROW-TRANSPLANTATION, DISEASE, GANCICLOVIR, INFECTION, VALACYCLOVIR, PROPHYLAXIS, PREVENTION, RECIPIENTS, EVASION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/171872
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item