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The incidence and cause of coagulopathies in an intensive care population

Chakraverty, R; Davidson, S; Peggs, K; Stross, P; Garrard, C; Littlewood, TJ; (1996) The incidence and cause of coagulopathies in an intensive care population. BRIT J HAEMATOL , 93 (2) 460 - 463.

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Abstract

We studied 235 patients admitted to an adult intensive care unit in order to determine the incidence and cause of coagulation disturbances, Clinical coagulopathy, defined as bleeding unexplained by local or surgical factors, was identified in 136% of patients. Laboratory evidence of coagulopathy was more common: a prothrombin time (PT) ratio greater than or equal to 1.5 was found in 66% of patients and a platelet count < 100 x 10(9)/l in 38% of patients. Both factors were predictive of excessive bleeding and poor outcome. In a retrospective analysis of plasmas from 45 of the above patients who had PT ratios greater than or equal to 1.5 the most common cause was vitamin K deficiency (20%).

Type: Article
Title: The incidence and cause of coagulopathies in an intensive care population
Keywords: vitamin K deficiency, intensive care, coagulopathy, VITAMIN-K DEFICIENCY, COAGULATION, FIBRINOLYSIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/171796
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