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A spatial variation model of white matter microstructure

Morgan, GL; Zhang, H; Whitcher, B; Alexander, DC; (2010) A spatial variation model of white matter microstructure. In: Zhang, H, (ed.) Proceedings of the Workshop on Computational Diffusion MRI (CDMRI'10), Medical Image Computing and Computer-Assisted Intervention (MICCAI 2010). (pp. 165 - 174). Green open access

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Abstract

In this study, we introduce a new technique to model the variation of microstructural parameters across speci c brain regions. We use a simple model of di usion in each voxel, but model the variation of parameters across the region using penalised splines. We t the whole region model directly to the di usion-weighted signals. We test the tech- nique on the mid-sagittal section of the corpus callosum (CC) using a di usion MRI data set with distinct age groups. The method detects di erences and separates the groups.

Type: Proceedings paper
Title: A spatial variation model of white matter microstructure
Event: CDMRI'10: MICCAI 2010 Workshop on Computational Diffusion MRI
Location: Beijing, China
Dates: 2010-09-18 - 2010-09-24
Open access status: An open access version is available from UCL Discovery
Publisher version: http://cmic.cs.ucl.ac.uk/cdmri10/
Language: English
UCL classification: UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/171428
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