UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Intramolecular amidocyclopropanation reactions using diethoxymethyl-functionalised lactams as organozinc carbenoid precursors

Jerome, L; Sheppard, TD; Aliev, AE; Motherwell, WB; (2009) Intramolecular amidocyclopropanation reactions using diethoxymethyl-functionalised lactams as organozinc carbenoid precursors. Tetrahedron Letters , 50 (26) 3709 - 3712. 10.1016/j.tetlet.2009.03.224. Green open access

[img]
Preview
PDF
170134_WBMIntraCyclopropanes.pdf
Available under License : See the attached licence file.

Download (128kB)

Abstract

Intramolecular amidocyclopropanation reactions of diethoxymethyl-lactams containing a pendant alkene were examined using zinc/TMSCI. With a range of 4-6-membered lactams, bicyclic amidocyclopropanes were obtained with very high diastereoselectivity with a preference for the formation of the More hindered endo-cyclopropane. (C) 2009 Elsevier Ltd. All rights reserved.

Type: Article
Title: Intramolecular amidocyclopropanation reactions using diethoxymethyl-functionalised lactams as organozinc carbenoid precursors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tetlet.2009.03.224
Publisher version: http://dx.doi.org/10.1016/j.tetlet.2009.03.224
Language: English
Keywords: Lactams, Carbenoids, Cyclopropanes, Zinc, Alkenes, DE-MEIJERE REACTION, REDUCTIVE CYCLOPROPANATION, BICYCLIC CYCLOPROPYLAMINES, MEDIATED CYCLOPROPANATION, STEREOSELECTIVE-SYNTHESIS, AMIDE GROUPS, ACID, ALKENES, AMINOCYCLOPROPANES, VINYLDIAZOMETHANES
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/170134
Downloads since deposit
106Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item