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SOCIAL CONTROLS ON CELL-SURVIVAL AND CELL-DEATH

RAFF, MC; (1992) SOCIAL CONTROLS ON CELL-SURVIVAL AND CELL-DEATH. NATURE , 356 (6368) 397 - 400.

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Abstract

Programmed cell death occurs in most animal tissues at some stage of their development, but the molecular mechanism by which it is executed is unknown. For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells. Such dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells. But how general is this dependence on survival signals?

Type: Article
Title: SOCIAL CONTROLS ON CELL-SURVIVAL AND CELL-DEATH
Keywords: NERVE GROWTH-FACTOR, MITOCHONDRIAL-MEMBRANE PROTEIN, FACTOR DEPRIVATION, LIVER HYPERPLASIA, PROGRAMMED DEATH, RAT-LIVER, C-KIT, APOPTOSIS, DELETION, BCL-2
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/170071
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