Brennan, PA; Palacios-Callender, M; Umar, T; Hughes, D; Spedding, AV; Zaki, GA; Langdon, JD; (2000) Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma. BRIT J ORAL MAX SURG , 38 (6) 627 - 632.
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Prolonged nitric oxide (NO) production by the enzyme type II nitric oxide synthase (NOS2) has been implicated in angiogenesis and metastasis of human cancers. In animal models, wild-type p53 (but not mutant) protein results in down-regulation of NOS2 expression, which reduces both tumour growth and dissemination. In the current study, we aimed to find out whether a correlation was present in oral squamous cell carcinoma. Fifty-six cases of squamous cell carcinoma were assessed immunohistochemically using antibodies to NOS2 and p53 (clone DO-7). We also confirmed NOS2 protein expression in selected cases using immunoblotting, The results were correlated with clinicopathological findings. Statistical analysis showed a significant relationship between p53 and NOS2 expression (P < 0.001). No relationship was found between size of tumour or histological degree of differentiation, and NOS2 expression in the primary tumour. (C) 2000 The British Association of Oral and Maxillofacial Surgeons.
|Title:||Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma|
|Keywords:||WILD-TYPE P53, TUMOR PROGRESSION, GENE-EXPRESSION, IN-VIVO, CANCER, HEAD, NECK, APOPTOSIS, GROWTH, ADENOCARCINOMA|
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