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Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations

Hausenloy, DJ; Baxter, G; Bell, R; Botker, HE; Davidson, SM; Downey, J; Heusch, G; ... Yellon, DM; + view all (2010) Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations. BASIC RES CARDIOL , 105 (6) 677 - 686. 10.1007/s00395-010-0121-4.

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Abstract

Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD. Although a large number of novel cardioprotective strategies have been discovered in the research laboratory, their translation to the clinical setting has been largely disappointing. The reason for this failure can be attributed to a number of factors including the inadequacy of the animal ischemia-reperfusion injury models used in the preclinical cardioprotection studies and the inappropriate design and execution of the clinical cardioprotection studies. This important issue was the main topic of discussion of the UCL-Hatter Cardiovascular Institute 6th International Cardioprotection Workshop, the outcome of which has been published in this article as the "Hatter Workshop Recommendations". These have been proposed to provide guidance on the design and execution of both preclinical and clinical cardioprotection studies in order to facilitate the translation of future novel cardioprotective strategies for patient benefit.

Type: Article
Title: Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations
DOI: 10.1007/s00395-010-0121-4
Keywords: Cardioprotection, Preconditioning, Postconditioning, Animal models, Translation, ACUTE MYOCARDIAL-INFARCTION, PERMEABILITY TRANSITION PORE, CARDIAC MAGNETIC-RESONANCE, ISCHEMIA-REPERFUSION INJURY, CORONARY MICROEMBOLIZATION, POSTCONDITIONING PROTECTS, DEPENDENT MECHANISM, RANDOMIZED-TRIALS, CLINICAL-THERAPY, HUMAN HEART
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/169484
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