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Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface

Piccirillo, C; Perni, S; Gil-Thomas, J; Prokopovich, P; Wilson, M; Pratten, J; Parkin, IP; (2009) Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface. J MATER CHEM , 19 (34) 6167 - 6171. 10.1039/b905495b.

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Abstract

Methylene Blue or Toluidine Blue O were covalently bound to an activated silicone polymer by means of an amide condensation reaction. UV-visible absorption spectra confirmed that the dye was surface bound. The new polymers with covalently attached dye display significant bactericidal activity against Escherichia coli and Staphylococcus epidermidis with a 99.999% reduction in viable bacteria after four minutes exposure to a low power laser.

Type: Article
Title: Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface
DOI: 10.1039/b905495b
Keywords: LETHAL PHOTOSENSITIZATION, LIGHT
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/169421
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