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The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles

Perni, S; Piccirillo, C; Pratten, J; Prokopovich, P; Chrzanowski, W; Parkin, IP; Wilson, M; (2009) The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. BIOMATERIALS , 30 (1) 89 - 93. 10.1016/j.biomaterials.2008.09.020.

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Abstract

We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log(10) reduction in the viable count when exposed for 5 min to light from a low power 660 nM laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nM gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria. (C) 2008 Elsevier Ltd. All rights reserved.

Type: Article
Title: The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles
DOI: 10.1016/j.biomaterials.2008.09.020
Keywords: Catheter, Hospital acquired infection, Polymer, Nanoparticle, Light-activated antimicrobial, INFECTIONS, PREVENTION, DEVICES
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/169352
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