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The structural biology of type IV secretion systems

Fronzes, R; Christie, PJ; Waksman, G; (2009) The structural biology of type IV secretion systems. NAT REV MICROBIOL , 7 (10) 703 - 714. 10.1038/nrmicro2218.

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Abstract

Type IV secretion systems (T4SSs) are versatile secretion systems that are found in both Gram-negative and Gram-positive bacteria and secrete a wide range of substrates, from single proteins to protein-protein and protein-DNA complexes. They usually consist of 12 components that are organized into ATP-powered, double-membrane-spanning complexes. The structures of single soluble components or domains have been solved, but an understanding of how these structures come together has only recently begun to emerge. This Review focuses on the structural advances that have been made over the past 10 years and how the corresponding structural insights have helped to elucidate many of the details of the mechanism of type IV secretion.

Type: Article
Title: The structural biology of type IV secretion systems
DOI: 10.1038/nrmicro2218
Keywords: T-DNA TRANSFER, AGROBACTERIUM-TUMEFACIENS VIRB7, COMPLEX TRANSPORT APPARATUS, PERTUSSIS TOXIN SECRETION, GRAM-NEGATIVE BACTERIA, ESSENTIAL VIRULENCE PROTEIN, CAG PATHOGENICITY ISLAND, TRAG-LIKE PROTEINS, HELICOBACTER-PYLORI, ESCHERICHIA-COLI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/168707
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