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Nanopore analytics: sensing of single molecules

Howorka, S; Siwy, Z; (2009) Nanopore analytics: sensing of single molecules. CHEM SOC REV , 38 (8) 2360 - 2384. 10.1039/b813796j.

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Abstract

In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).

Type:Article
Title:Nanopore analytics: sensing of single molecules
DOI:10.1039/b813796j
Keywords:SOLID-STATE NANOPORE, DNA HAIRPIN MOLECULES, ION-CURRENT RECTIFICATION, TRANSVERSE ELECTRONIC TRANSPORT, PROTEIN-LIGAND INTERACTIONS, SEQUENCE-SPECIFIC DETECTION, TUNABLE NANOFLUIDIC DIODE, CHANNEL-FORMING PEPTIDES, LIPID-BILAYER MEMBRANE, NANOMETER-SCALE PORE
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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