UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

Chan, LF; Webb, TR; Chung, TT; Meimaridou, E; Cooray, SN; Guasti, L; ... Clark, AJL; + view all (2009) MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. P NATL ACAD SCI USA , 106 (15) 6146 - 6151. 10.1073/pnas.0809918106.

Full text not available from this repository.

Abstract

The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R-MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic-pituitary adrenal axis, whereas MC3R and MC4R have an essential role in energy homeostasis. Mutations in MC4R are the single most common cause of monogenic obesity. Investigating the way in which these receptors signal and traffic to the cell membrane is vital in understanding disease processes related to MCR dysfunction. MRAP is an MC2R accessory protein, responsible for adrenal MC2R trafficking and function. Here we identify MRAP2 as a unique homologue of MRAP, expressed in brain and the adrenal gland. We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling. In contrast, MRAP and MRAP2 can reduce MC1R, MC3R, MC4R, and MC5R responsiveness to [Nle4, D-Phe7] alpha-melanocyte-stimulating hormone (NDP-MSH). Collectively, our data identify MRAP and MRAP2 as unique bidirectional regulators of the MCR family.

Type:Article
Title:MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
DOI:10.1073/pnas.0809918106
Keywords:GPCR accessory proteins, receptor signalling, receptor trafficking, FAT MASS, OBESITY, MOUSE, MC4R, EXPRESSION, MUTATIONS, CELLS, GENE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health

Archive Staff Only: edit this record