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Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin

Boureau, YL; Dayan, P; (2011) Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin. NEUROPSYCHOPHARMACOL , 36 (1) 74 - 97. 10.1038/npp.2010.151.

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Abstract

Affective valence lies on a spectrum ranging from punishment to reward. The coding of such spectra in the brain almost always involves opponency between pairs of systems or structures. There is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. In this review, we consider the structure of opponency in terms of previous biases about the nature of the decision problems that animals face, the conflicts that may thus arise between Pavlovian and instrumental responses, and an additional spectrum joining invigoration to inhibition. We use this analysis to shed light on aspects of the role of serotonin and its interactions with dopamine. Neuropsychopharmacology Reviews (2011) 36, 74-97; doi: 10.1038/npp.2010.151; published online 29 September 2010

Type: Article
Title: Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin
DOI: 10.1038/npp.2010.151
Keywords: dopamine, norepinephrine, opponency, psychiatry and behavioral sciences, reinforcement learning, serotonin, MEDIAL PREFRONTAL CORTEX, DORSAL RAPHE NUCLEUS, VENTRAL TEGMENTAL AREA, PAVLOVIAN-INSTRUMENTAL TRANSFER, ANTERIOR CINGULATE CORTEX, IN-VIVO MICRODIALYSIS, BASOLATERAL AMYGDALA NEURONS, 5-HT2C RECEPTOR ANTAGONISTS, MEDIUM SPINY NEURONS, CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neuroscience Unit
URI: http://discovery.ucl.ac.uk/id/eprint/168537
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