Bajwa, A; Blunt, N; Vyas, S; Suliman, I; Bridgewater, J; Hochhauser, D; ... O'Bichere, A; + view all Bajwa, A; Blunt, N; Vyas, S; Suliman, I; Bridgewater, J; Hochhauser, D; Ledermann, JA; O'Bichere, A; - view fewer (2009) Primary tumour resection and survival in the palliative management of metastatic colorectal cancer. EJSO , 35 (2) 164 - 167. 10.1016/j.ejso.2008.06.005.
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Aim: To examine whether surgical resection of the primary tumour confers a survival benefit and to identify the predictive factors of outcome in patients presenting with asymptornatic metastatic colorectal cancer (CRC).Materials and methods: A review of a hospital database in a tertiary institution over a 6-year period (1999-2005) revealed 70 patients with asymptomatic primary CRC and unresectable liver metastases treated initially by systemic chemotherapy. A multivariate regression analysis model was used to determine the relative influence of multiple tumours, single/multiple liver metastases, tumour site, differentiation, response of liver and primary tumour to chemotherapy, biochemical response to chemotherapy, age at presentation, performance status and surgical intervention for the CRC primary.Results: In 67 cases (3 lost to follow-up), 63 had multiple anti 4 single surgically irresectable liver metastases. A total of 41 deaths were recorded. All patients received systemic chemotherapy and surgery was performed for bowel obstruction, bleeding or stable disease (n = 32). Surgery (OR 0.26; p = 0.00013) and clinical response of the primary tumour (OR 0.53; p = 0.012) were independently associated with prolonged survival. Proximal tumours (OR 2.61; p = 0.0075) and multiple primaries (OR 3.37; p = 0.02) were associated with poor outcome.Conclusions: Surgical resection and response of the primary tumour to chemotherapy may be associated with improved survival, but proximal or multiple cancers predict poor outcome in patients with asymptomatic CRC and unresectable metastatic disease. (C) 2008 Elsevier Ltd. All rights reserved.
|Title:||Primary tumour resection and survival in the palliative management of metastatic colorectal cancer|
|Keywords:||Palliative, Metastatic, Colorectal cancer, Resection, Primary tumour, SYNCHRONOUS METASTASES, MUCINOUS CARCINOMA, 1ST-LINE TREATMENT, RANDOMIZED-TRIAL, COLON, CHEMOTHERAPY, SURGERY, FOLFOX6, LIVER|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > CRUK Cancer Trials Centre
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Oncology
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