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Structure of a Type IV Secretion System Core Complex

Fronzes, R; Schafer, E; Wang, LC; Saibil, HR; Orlova, EV; Waksman, G; (2009) Structure of a Type IV Secretion System Core Complex. SCIENCE , 323 (5911) 266 - 268. 10.1126/science.1166101.

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Abstract

Type IV secretion systems (T4SSs) are important virulence factors used by Gram- negative bacterial pathogens to inject effectors into host cells or to spread plasmids harboring antibiotic resistance genes. We report the 15 angstrom resolution cryo- electron microscopy structure of the core complex of a T4SS. The core complex is composed of three proteins, each present in 14 copies and forming a similar to 1.1- megadalton two-chambered, double membrane- spanning channel. The structure is double- walled, with each component apparently spanning a large part of the channel. The complex is open on the cytoplasmic side and constricted on the extracellular side. Overall, the T4SS core complex structure is different in both architecture and composition from the other known double membrane- spanning secretion system that has been structurally characterized.

Type: Article
Title: Structure of a Type IV Secretion System Core Complex
DOI: 10.1126/science.1166101
Keywords: AGROBACTERIUM-TUMEFACIENS, PROTEIN SUBASSEMBLIES, ESCHERICHIA-COLI, VIRB9, DNA, BIOGENESIS, MACHINERY, SUBSTRATE, MEMBRANES, COMPONENT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/168513
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