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Mitochondrial morphology and cardiovascular disease

Ong, SB; Hausenloy, DJ; (2010) Mitochondrial morphology and cardiovascular disease. CARDIOVASC RES , 88 (1) 16 - 29. 10.1093/cvr/cvq237.

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Abstract

Mitochondria are dynamic and are able to interchange their morphology between elongated interconnected mitochondrial networks and a fragmented disconnected arrangement by the processes of mitochondrial fusion and fission, respectively. Changes in mitochondrial morphology are regulated by the mitochondrial fusion proteins (mitofusins 1 and 2, and optic atrophy 1) and the mitochondrial fission proteins (dynamin-related peptide 1 and mitochondrial fission protein 1) and have been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy, although the majority of studies have been largely confined to non-cardiac cells. Despite the unique arrangement of mitochondria in the adult heart, emerging data suggest that changes in mitochondrial morphology may be relevant to various aspects of cardiovascular biology-these include cardiac development, the response to ischaemia-reperfusion injury, heart failure, diabetes mellitus, and apoptosis. Interestingly, the machinery required for altering mitochondrial shape in terms of the mitochondrial fusion and fission proteins are all present in the adult heart, but their physiological function remains unclear. In this article, we review the current developments in this exciting new field of mitochondrial biology, the implications for cardiovascular physiology, and the potential for discovering novel therapeutic strategies for treating cardiovascular disease.

Type: Article
Title: Mitochondrial morphology and cardiovascular disease
DOI: 10.1093/cvr/cvq237
Keywords: Mitochondrial morphology, Mitochondrial dynamics, Ischaemia-reperfusion injury, Mitochondrial fusion, Mitochondrial fission, PERMEABILITY TRANSITION PORE, DYNAMIN-RELATED PROTEIN, CYTOCHROME-C RELEASE, DOMINANT OPTIC ATROPHY, MUSCLE-CELL APOPTOSIS, MAMMALIAN-CELLS, ENDOPLASMIC-RETICULUM, CARDIAC MITOCHONDRIA, GIANT MITOCHONDRIA, REPERFUSION INJURY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/168442
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